Stereochemical Aspects of Nucleophilic Substitution Reactions of Haloalkanes and Haloarenes

IMPORTANT

Stereochemical Aspects of Nucleophilic Substitution Reactions of Haloalkanes and Haloarenes: Overview

This topic consists of concepts such as Optical Isomers or Enantiomers and Optical Isomerism, Nicol Prism and Plane Polarised Light, Le Bel - Van't Hoff Rule, Racemic Mixture, etc.

Important Questions on Stereochemical Aspects of Nucleophilic Substitution Reactions of Haloalkanes and Haloarenes

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IMPORTANT

What kind of reagent would be needed to resolve a racemic amine, such as 2-aminobutane?

EASY
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A pure simple of 2-chlorobutane shows rotation of PPL by 30o in standard conditions. When above samples is made impure by mixing its opposite form, so that the composition of the mixture become 87.5 % d-form and 12.5 % l-form, then what will be the observed rotation for the mixture.

EASY
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If during a reaction, the product has the same general configuration of groups around the stereocentre as that of reactant. Such a reaction is said to proceed with:

MEDIUM
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Which of the following method is not used in the resolution of a racemic mixture?

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Which of the following is taken as a reference to represent the relative configuration?

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Which of the following compounds will give racemic mixture on nucleophilic substitution by OH- ion? Question Image

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 Compound A with molecular formula C6H12 has chirality but on hydrogenation compound A is converted into C6H14 compound B in which chirality disappear compound A is:

MEDIUM
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A solution of (−)−1-chloro-1-phenylethane in toluene racemises slowly in the presence of small amount of SbCl5, due to the formation of